Lornoxicam

Lornoxicam (Xefocam) is a selective COX-2 inhibitor. It refers to the group of oxicams. It has a prominent anti-inflammatory and especially analgesic activity (it is comparable to morphine and more potent than Tramadol by the action on postoperative and traumatic pains). 

Pharmacokinetics. Taken orally, it is quickly and completely absorbed, bioavailability – up to 100%, Сmax (administered per os) – in 15 min. t1|2 – 4 h. Biotransformation – in liver; excreted – with bile.

Indications: arthritis (rheumatoid, psoriatic, gouty, infectious), Bechterew’s disease, radicular syndrome, osteochondrosis, myalgia, postoperative and posttraumatic pains.

Prescription: orally and parenterally.

Orally – before meal with enough amount of water. Initial dose ( on the 1st day) – 0,016-0,032 g, then – 0,008 g 2 times a day.

For the relief of acute pain syndrome, one injects 0,008-0,016 g i/m or i/v.

Adverse reactions: erosive-ulcerative involvements and hemorrhages in GIT, dyspepsia, renal and hepatic dysfunction, sleepiness, depression or agitation, arterial hypertension, peripheral edema, sweating, leucopenia, thrombocytopenia, skin allergic reactions.  

Contraindications: gastric and duodenal ulcers, inflammatory diseases of intestines, BA, hepatic and renal dysfunction, congestive heart failure, arterial hypertension, leuco-, thrombocytopenia, pregnancy, lactation, age under 18 and older 60. 

Interactions: NSAIDs and indirect anticoagulants increase the risk of Lornoxicam side effects. Lornoxicam intensifies the hypoglycemic  activity of sulphonilurea derivatives, weakens the diuretic effect and increases nephrotoxicity of diuretics.  

It should be used with caution while performing any kinds of potentially dangerous activities requiring concentration of attention and immediate reactions. 

Dosage forms: 0,004 and 0,008 g tab.; frozen-dried powder for the injection solutions in bottles – 0,008 g.